Hmmm by 2s2p, do you mean putting 1&3 in series, 2&4 in series, and then paralleling those two sets? I didn't think of that.
Yes @Rednecktek you're right, didn't notice that voltage nerfing about config 2. Definitely kills it.
So config 3 is similar to a 2s2p, except there are shading issues...